Negative effect of the sun light on important epidermal genes

What is it about?

rClCa2 is associated with epidermal differentiation, we found that it was strongly down-regulated by exposure to the main component of solar radiation UVb, this might be one of the way sun exposure leads to skin cancer

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Why is it important?

rClCA2 is a differentiation associated molecule and its downregulation could lead to cancer Most importantly this gene is associated with tumor-suppressor effect