What is it about?
Transient elastography is a non-invasive method for staging liver fibrosis. The meta-analysis using the hierarchical models to evaluate the diagnostic accuracy of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B was rarely reported.
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Why is it important?
Twenty-seven studies with a total of 4386 patients were included in the meta-analysis. The summary sensitivity of transient elastography for staging fibrosis F ≥ 2, F ≥ 3 and F = 4 was 0.806, 0.819 and 0.863, respectively, and the summary specificity was 0.824 , 0.866 and 0.875 ,respectively. The corresponding area under the summary receiver operating characteristic curve was 0.88 ,0.91 and 0.93 , respectively. Meta-regression showed that patient age contributed to heterogeneity. Transient elastography performs well to diagnose liver fibrosis in patients with chronic hepatitis B, which may reduce the use of liver biopsy.
Perspectives
Our research is a comprehensive report using an optimal statistical method HSROC to evaluate diagnostic accuracy of TE in a total of 4386 CHB patients. In addition, meta-regression was used in this study to further investigate the effects of the average age of patients, the minimal length of LB specimen and mean ALT level on the diagnostic accuracy of TE. The strict selection criteria also included the limitation of interval between TE and LB. In this way, our study provides a good reference value for diagnosing liver fibrosis in CHB patients.
Dr Xueen Liu
Peking University Health Science Center
Read the Original
This page is a summary of: Systematic review with meta-analysis: the diagnostic accuracy of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B, Alimentary Pharmacology & Therapeutics, December 2015, Wiley,
DOI: 10.1111/apt.13488.
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