Lipoarabinomannan-specific TNF-α and IFN-γ as markers of protective immunity against tuberculosis

What is it about?

Identifying biomarkers of protection against TB is an important step for vaccine development. In this paper, we showed that LAM-induced cytokines could be used as biomarkers of protective immunity against TB.

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Why is it important?

Identifying biomarkers of protection in TB is key for vaccine development and evaluation. Unfortunately, there are no biomarkers of protection identified and this paper examined the potential of LAM-induced cytokines as biomarkers of protection. The paper showed that LAM-induced IFN-gamma and TNF-alpha could be considered as potential markers of protection.