What is it about?
the aim of this study was to evaluate the protective effects of FSE on CIS-induced alterations in sperm characteristics and biochemical changes related to oxidative stress and inflammations in the testes of rats.
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Why is it important?
Fenugreek seeds are a rich source of many active phytochemicals such as alkaloids, trigonelline, steroidal saponins, salicylate, nicotinic acid and flavonoids, which are thought to account for
Perspectives
We believe that the protective effects of FSE against CIS-reproductive toxicity is mediated primarily through both the inhibition of apoptosis and the abrogation of oxidative stress and iNOS and NF-jB inflammatory response associated with CIS treatment. These observations are of clinical importance as FSE could be a promising target to halt this serious testicular toxicity induced by CIS.
Dr Alaaeldin A Hamza
National Organization for Drug Control and Research
Read the Original
This page is a summary of: Fenugreek seed extract attenuates cisplatin-induced testicular damage in Wistar rats, Andrologia, May 2015, Wiley,
DOI: 10.1111/and.12435.
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