What is it about?
Hypoxia-inducible factor (HIF) contributes to the adaptation of tumor cells to hypoxic conditions, so genetic polymorphisms involved in this pathway may affect cellular response to hypoxia and be associated with cancer risk. Thus, we examined the association between the lung cancer risk and genetic polymorphisms involved in the HIF pathway.
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Why is it important?
Hypoxia-inducible factor 2A rs13419896 and vascular endothelial growth factor A rs833061 were significantly related to lung cancer risk, with possible interaction between polymorphisms and cigarette smoking.
Perspectives
Findings from polymorphism-environment interaction analyses must be interpreted with caution because of limited numbers of observations in the subgroups. Therefore, replication of the studies with a large number of cases and controls is required to confirm our findings.
Chikako KIyohara
Read the Original
This page is a summary of: Association between genetic polymorphisms involved in the hypoxia-inducible factor pathway and lung cancer risk: a case-control study in Japan, Asia-Pacific Journal of Clinical Oncology, December 2016, Wiley,
DOI: 10.1111/ajco.12640.
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