What is it about?
The dopamine transporter gene DAT1 (SLC6A3) has been suggested to play a role in both depression and specific personality traits. Using five polymorphisms of DAT1 in 463 patients with major depression (MD) , we found evidence of lower novelty seeking score (NS) in early-onset MD patients with the G/G genotype of rs2550948 and the T/T genotype of rs2975226, compared to patients with other genotypes.
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Why is it important?
Our study suggests that the DAT1 promoter variants possible influence specific personality traits in early-onset subgroup of depressed patients among Han Chinese population. Further prospective cohort studies are required to verify our preliminary finding and to confirm the effects of personality susceptibility on long-term disease outcomes.
Perspectives
I think this article add an interesting topic of the association of DAT1 and personality traits to the literature.
Dr San-Yuan HUang
Tri-Service General Hospital
Read the Original
This page is a summary of: The dopamine transporter gene possibly affects personality traits in patients with early-onset major depressive disorder, Acta Neuropsychiatrica, March 2013, Cambridge University Press,
DOI: 10.1111/acn.12019.
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