What is it about?
This work identifies alcohol stimulation of iNOS and resulting activation of miR-212 production as a novel mechanism for alcohol promotion of leaky gut and resulting alcoholic steatohepatitis.
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Why is it important?
This work identifies a novel role for iNOS as well as miR-212 in regulation of intestinal permeability in response to alcohol.
Perspectives
This work establishes a novel epigenetic microRNA based mechanism for regulation of alcohol-induced leaky gut that could provide new biomarkers as well as potential targets for therapy.
Dr Ali Keshavarzian
Rush University Medical Center
Read the Original
This page is a summary of: The Role of miR-212 and iNOS in Alcohol-Induced Intestinal Barrier Dysfunction and Steatohepatitis, Alcoholism Clinical and Experimental Research, July 2015, Wiley,
DOI: 10.1111/acer.12813.
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