What is it about?
Article focuses on the pathway of inflammation. It shows that there is a effector arm, an amplification arm and one initiatiation arm. Most research is on the effector arm. The article focuses more on the amplification arm and suggests that colchicine blocks the production of IL1beta.
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Why is it important?
It is important in highlighting that it may be worthwhile targeting more proximal pathways.
Perspectives
This article brings a new perspective to understanding inflammation. The initiation pathways may be different. But amplificatory and effector pathways are common for all kinds of inflammation.
Prof. Siddharth K Das
K. G. Medical University, Lucknow, India
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This page is a summary of: Current biological understanding and futuristic views for osteoarthritis treatment: Optimistic or otherwise?, International Journal of Rheumatic Diseases, March 2016, Wiley,
DOI: 10.1111/1756-185x.12865.
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