What is it about?
Some findings has been observed in obesity, such as low-grade inflammation, increasing of saturated fatty acid, and low level of vitamin D. Since fatty acid known to induce inflammation, and vitamin D known as anti-inflammation. What will happen if we add vitamin D into monocytes that has exposed to saturated fatty acid and LPS? Can vitamin D reduced the pro-inflammatory cytokines of monocytes? In our finding, this was not the case. The pro-inflammatory cytokines did not reduced, but increased. Increasing of these cytokines was not calcium-dependent process.
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Why is it important?
Many studies support anti-inflammatory activity of vitamin D in obesity. Unfortunately, clinical trial in obesity patients found no benefit of vitamin D supplementation for obesity. Our finding support this conclussion.
Perspectives
It was my pleasure to work under the best advisor in the world. His point of view, expertise, and kindness were broadening my knowledge and improving my personality. To have a result different with what majority believe was intriguing, since we need to have evidence to support our findings. Fortunately, many clinical trials, similarly, did not observed beneficial effect of vitamin D in obesity.
annette darqom
Universitas Airlangga
Read the Original
This page is a summary of: Effects of 1α,25 DihydroxyvitaminD3on Pro-inflammatory Cytokines of Palmitic Acid Treated Thp-1 Cells, Journal of Food Science, November 2017, Wiley,
DOI: 10.1111/1750-3841.13966.
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