Re: Progesterone-receptor genetic variants and susceptibility to recurrent-pregnancy loss

What is it about?

I, Dr. Saumya Pandey Ph.D., wish to provide a snapshot of my successful clinical research contribution; my meticulously drafted article highlights the emerging role of Progesterone receptor gene polymorphisms in susceptibility to recurrent pregnancy loss. Association case-control gene-epidemiology research studies are warranted to provide spectacular gains in our current understanding of the complex etiopathogenesis of pregnancy-related aberrations and/or disorders in women of ethnically disparate populations worldwide; a statistically powered study with stringent inclusion/exclusion criteria and large sample size is essential to provide clinically significant data with definitive conclusions. Progesterone receptor-mediated signaling offers immense immunotherapeutic potential for successful and cost-effective design of predictive biomarkers in management of recurrent pregnancy loss in women of child-bearing age.

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Why is it important?

I constantly endeavor to contribute to the ever-expanding field of reproductive medicine including pregnancy-related metabolic aberrations/disorders including miscarriages and recurrent pregnancy loss. As an Asian Indian female/woman scientist/clinical researcher/public health expert, I am overwhelmed to observe the differential trends in pregnancy-related outcomes, including recurrent pregnancy loss, miscarriages, infertility, stillbirths, etc, in ethnically disparate cohorts of women including North Indian, South Indian as well as North American women of varying lifestyles, dietary patterns and cultural exposures. My article critically addresses the increasing trends in recurrent pregnancy loss in a specific patient population subset; sample size and subgroup stratification based on clinically relevant confounders and/or variables/parameters are important factors in designing robust, reproducible and significant case-control studies in reproductive medicine; an impressive sample size with well-structured questionnaires including adherence to good clinical practice research guidelines are warranted to provide reliable, bias-free genetic association data-sets. However, study limitations should be considered while replicating case-control findings in diverse populations; multi-centric study designs may yield cost-effective public health research models in patient-friendly tailor-made treatment modalities. Eventually, Progesterone receptor genetic variants may be investigated with interrelated receptors polymorphisms including Toll-like receptors, Frizzled receptors and/or Cyclooxygenase-2 genetic variants in Indian women including North Indian women, and findings amalgamated in a pooled case-control cohort involving women of diverse geographical locations/ethnicities.

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