What is it about?
bHLH transcription factor Crf1 is a regulatory factor of carbohydrate and lipid metabolism in the rice blast fungus. Crf1 positively regulates lipid degradation, β-oxidation, glyoxylate cycle, gluconeogenesis and glycerol metabolism. Crf1 is required for the utilization of several carbon sources, such as glycerol, ethanol, arabinose and leucine. Crf1 is also required for conidial cell death and fungal virulence on rice.
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Why is it important?
Our findings show that the carbon metabolism is cooperatively regulated by both Crf1 positively and CreA negatively in the fungus.
Perspectives
I hope this article will make people to understand the alteration of nutrition mode in pathogenic fungi more deeply. The fungi change their carbon metabolism pathways according to different environmental carbon sources.
Dr Jianping Lu
Zhejiang University
Read the Original
This page is a summary of: The basic helix-loop-helix transcription factor Crf1 is required for development and pathogenicity of the rice blast fungus by regulating carbohydrate and lipid metabolism, Environmental Microbiology, September 2018, Wiley,
DOI: 10.1111/1462-2920.14387.
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