Losartan & atorvastatin in rats with liver fibrosis

What is it about?

This study was designed to examine the anti-fibrotic effect of losartan (AT1 receptor blocker) and atorvastatin, either as monotherapy or as combined therapy and to investigate their role in preventing or regressing liver fibrosis in rats.

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Why is it important?

Few studies investigated the combined effects of Angiotensin II antagonist and statins in vitro; meanwhile our study represents a new addition to examine the combined effect of losartan and atorvastatin in vivo in CCl4 intoxicated rat model. Our results indicated that the combination of losartan and atorvastatin, rather than either drug alone, exerted better preventive and therapeutic effects on hepatic fibrosis in rats and proved a beneficial role in inhibiting or reversing liver fibrosis. Because our findings could be applied in the clinic right away, they are likely to be of great interest to the researchers, clinicians, and trainees.