What is it about?
Leishmania donovani is a parasite that usually spreads throughout the body organs such as spleen and liver to cause severe disease. But majority of infections with this parasite is limited to the skin in Sri Lankan patients. This paper describes the host immune response to this parasite.
Why is it important?
The host immune response may have a role in localization of the parasite to the skin. Predominant host cytokine profile, in the form of Th1 or Th2 will determine the outcome of the disease. We have quantified the Th1 and Th2 response to the parasite and also explored the pathological feature in the skin lesions. We have identified in Sri Lankan patients, an increased production of Th1 cytokines that usually leads to disease cure.
The following have contributed to this page: Dr. Nuwani H Manamperi and Prof. Nadira D. Karunaweera
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