What is it about?

Chymotrypsin-Trypsin are proteolytic enzymes, indicated for reducing soft tissue edema and inflammation as they hasten the healing of damaged tissues and thereby, promotes a complication free recovery. So , we did used this proteolytic enzyme in combination with Diclofenac Potassium to compare the adjuvant effect on the postoperative sequelae management , when compared to Diclofenac Potassium alone.

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Why is it important?

The adjuvant action of Chymotrypsin-trypsin on Diclofenac Potassium was found to be clinically and statistically superior than the use of Diclofenac Potassium alone for management of post-operative sequelae after extraction of impacted mandibular third molars. The research assessed the parameters such as pain, swelling, trimus and interincisal opening after the third molar surgery amongst both the groups and reported a significantly better results with clinically evident reduction in swelling, trismus and interincisal opening with the use of Chymotrypsin-Trypsin.


I would like make the readers and dentists practicing globally aware of the multifaceted benefits of the Combination Drug : Chymotrypsin-Trypsin with Diclofenac Potassium. The adjuvant effect seems to be a promising treatment modality, and a better alternative to using NSAID's alone for a good quality of life, aiding in reduction of postoperative sequeale following mandibular third molar disimpactions.

Swami Devi Dyal Group of Professional Institutions

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This page is a summary of: Trypsin‐chymotrypsin as an adjuvant to diclofenac potassium on the postoperative sequelae following mandibular third molar impactions—A comparative study, Oral Surgery, April 2022, Wiley, DOI: 10.1111/ors.12742.
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