Transgenerational phenotype aggravation in CAF‐1 mutants reveals parent‐of‐origin specific epigenetic inheritance

What is it about?

Typically, mutating a gene causes specific and stable effects on the phenotype. In contrast, we describe here how mutation of Chromatin Assembly Factor 1 initiates a series of epigenetic changes through subsequent generations of offspring that lead to transgenerational aggravation of the mutant phenotype. These defects have preferred maternal transmission revealing a more efficient erasure of epigenetic memory in the male than the female germline.

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