VanG‐ and D‐Ala‐D‐Ser‐dependent peptidoglycan synthesis and vancomycin resistance in Clostridioides difficile

What is it about?

Clostridioides difficile cells are sensitive to vancomycin, a first-line drug for treating C. difficile infection, despite possessing vancomycin resistance genes. Mutations that highly increase expression of these genes also increase cells' resistance to vancomycin but only moderately.

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