Mycoplasma hyopneumoniae membrane protein Mhp271 interacts with host UPR protein GRP78 to facilitate infection

What is it about?

We previously found that M. hyopneumoniae interferes with the host UPR to foster bacterial adhesion and infection. However, the underlying molecular mechanism of this UPR modulation is unclear. In this study, we demonstrate for the first time that host GRP78 as a target for M. hyopneumoniae Mhp271 modulates the host UPR to facilitate M. hyopneumoniae adherence and infection.

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