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In S. aureus, Teg49 is a trans-acting regulatory sRNA located in the 5’ UTR of the sarA mRNA, which encodes a DNA binding protein that regulates key virulence pathways. In this study, we showed that Teg49 regulates genes distinct from SarA. Using mutagenesis and phenotypic assays, we discovered that Teg49 regulates virulence by degrading the mRNA of SPIN, a myeloperoxidase inhibitor that hinders neutrophil killing of S. aureus in the phagolysosome.

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This page is a summary of: Regulation of neutrophil myeloperoxidase inhibitor SPIN by the small RNA Teg49 in Staphylococcus aureus, Molecular Microbiology, May 2022, Wiley,
DOI: 10.1111/mmi.14919.
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