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The PNSA loop in the ribosomal protein uS12 is universally conserved and has been studied in the context of translation elongation. Using Escherichia coli, we show additional roles the PNSA loop plays in ribosome biogenesis, ribosome association, and the fidelity of translation initiation. Also, our studies reveal genetic interactions between the PNSA loop and RRF. In addition, IF3 initiation from AUU codon may be linked to its (IF3) role in mitigating initiation from non-AUG codons.

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This page is a summary of: A mutation in the ribosomal protein uS12 reveals novel functions of its universally conserved PNSA loop, Molecular Microbiology, January 2021, Wiley, DOI: 10.1111/mmi.14675.
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