Environmental sensing and regulation of motility in Toxoplasma

What is it about?

Toxoplasma parasites cause toxoplasmosis which can lead to blindness, neurological problems and birth defects. Sensing of environmental cues is of central importance in regulating infectivity in Toxoplasma. Recently there has been major advances in understanding the molecular events underpinning this process in Toxoplasma; new environmental signals have been revealed, the first understanding of how parasites sense these and how they are transduced to regulate infectivity. Here we review these findings, integrating these into what we already understand and propose new questions that appear most important to understand.

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