What is it about?
The most lethal malaria parasite, Plasmodium falciparum, rapidly adapts to acquire drug resistance. For the first time, we report that highly resistant Plasmodium parasites carry additional copies of resistance-conferring genes separate from the genome, which are known as extra-chromosomal DNA (ecDNA). This finding provides a new model to study a fundamental mechanism of adaptation that is relevant in many microbes and may lead to a new way to target malaria.
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This page is a summary of: Extrachromosomal DNA amplicons in antimalarial‐resistant
Plasmodium falciparum, Molecular Microbiology, November 2020, Wiley, DOI: 10.1111/mmi.14624.
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