Calcium homeostasis plays important roles in the internalization and activities of the small synthetic antifungal peptide PAF26

What is it about?

Life threatening diseases can be caused when fungi invade human tissues, often occurring when a person’s immune defences are down. There is also a worrying rise in drug resistance seen in fungi sampled from patients, with infections effectively untreatable – a death sentence. Antifungal peptides such as PAF26 provide a possible solution by offering a cheap and rapidly produced alternative to conventional drugs. However, unlike antibacterial peptides, little is known about how these small molecules function.

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