Phosphoenolpyruvate carboxylase from the cyanobacterium Synechocystis sp. PCC 6803 is under global metabolic control by PII signaling

What is it about?

Phosphoenolpyruvate carboxylase (PEPC) is the second major carbon-fixing enzyme in Cyanobacteria, required to refill the TCA cycle and to convert phosphoenol pyruvate to pyruvate via a malate shunt. Here we show that the global metabolic control protein PII binds to PEPC and regulates its activity. PII-ATP activates PEPC and this activation is counteracted by 2-oxoglutarate.

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