Two transcription factors cooperatively regulate DHN melanin biosynthesis and development in Pestalotiopsis fici

What is it about?

DHN melanin is ubiquitous in fungi and crucial to fungal adaption for environment. Here, we show that two transcription factors PfmaF and PfmaH coordinately regulate melanin production and contribute to cell wall synthesis. PfmaH acts as a pathway specific regulator in the biosynthesis of DHN melanin. PfmaF functions as a broad regulator to stimulate PfmaH expression in melanin production, secondary metabolism as well as fungal development.

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