What is it about?
Lipoate is an essential cofactor for key enzymes of oxidative and one-carbon metabolism. In contrast to proteobacteria, Bacillus subtilis requires the activity of an amidotransferase, LipL, to both synthesize and scavenge this cofactor.
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Why is it important?
This new lipoyl-relay required for lipoate scavenging highlights the relevance of the amidotransferase as a valid target for the design of new antimicrobial agents among Gram-positive pathogens.
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This page is a summary of: Unravelling the lipoyl‐relay of exogenous lipoate utilization in
Bacillus subtilis, Molecular Microbiology, May 2019, Wiley,
DOI: 10.1111/mmi.14271.
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