The Campylobacter jejuni helical to coccoid transition involves changes to peptidoglycan and the ability to elicit an immune response

What is it about?

Campylobacter jejuni helical shape is key to its pathogenesis. Under stress, C. jejuni alters its shape from helical to coccoid. This study characterized C. jejuni bacterial cell wall peptidoglycan changes occurring during coccoid formation and identified a role for the peptidoglycan hydrolases Pgp1 and previously uncharacterized AmiA in the process. In addition, we determined that coccoid C. jejuni are non-pathogenic, being no longer able to infect human epithelial cells or trigger an immune response.

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