Iron‐sulfur cluster carrier proteins involved in the assembly of Escherichia coli NADH:ubiquinone oxidoreductase (complex I)

What is it about?

Escherichia coli respiratory complex I, a central enzyme complex of energy metabolism, contains nine iron-sulfur clusters as cofactors. We show that the deletion of genes coding the putative iron-sulfur cluster carrier proteins Mrp and NfuA significantly affects complex I activity and assembly. Furthermore, BolA, a poorly characterized protein seems to be important for the incorporation of one specific binuclear cluster called N1b into the complex.

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