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Despite its clinical importance, relatively little is known about the molecular basis of <i>Acinetobacter baumannii</i> pathogenesis. Using a transposon-sequencing (Tn-Seq) screen and the mouse model of bloodstream infection, we identified the lytic transglycosylase MltB as being a critical fitness factor in <i>A. baumannii</i>. In this study, we showed that MltB is part of a complex network connecting resistance to stresses, cell envelope homeostasis, biogenesis of pili and <i>in vivo fitness</i>.

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This page is a summary of: The lytic transglycosylase MltB connects membrane homeostasis and in vivo fitness of Acinetobacter baumannii , Molecular Microbiology, June 2018, Wiley,
DOI: 10.1111/mmi.14000.
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