RbpA and σB association regulates polyphosphate levels to modulate mycobacterial isoniazid-tolerance

  • RbpA and σB associate to regulate INH-tolerance
  • Zhongwei Wang, Bridgette M. Cumming, Chunyou Mao, Yan Zhu, Pei Lu, Adrie J.C. Steyn, Shiyun Chen, Yangbo Hu
  • Molecular Microbiology, April 2018, Wiley
  • DOI: 10.1111/mmi.13952

Polyphosphate contributes to isoniazid tolerance in mycobacteria

What is it about?

Drug-tolerant cells that can tolerate bactericidal concentrations of drugs without genetic mutations. Here we show a novel regulatory pathway for controlling the formation of isoniazid-tolerant cells in Mycobacterium smegmatis.

Why is it important?

Novel transcriptional regulational machnism was determined in mycobacterial isoniazid tolerance: RbpA and σB association regulate ppk1 transcription to control contents of polyphosphate, and then modulate stress-induced tolerance in group and may function in tolerance of indiviral cell.

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The following have contributed to this page: Yangbo Hu, Dr Shiyun Chen, and zhongwei wang