ClpC and MecA, components of a proteolytic machine, prevent Spo0A-P-dependent transcription without degradation

Andrew W. Tanner, Valerie J. Carabetta, David Dubnau
  • Molecular Microbiology, February 2018, Wiley
  • DOI: 10.1111/mmi.13928

What is it about?

MecA and ClpC inhibit the transcription of genes that are activated by Spo0A-P but do not de-repress those that are repressed. This suggests that MecA and ClpC do not prevent Spo0A-P binding to its target promoters. Instead, in vitro and in vivo data support a model in which these proteins assemble with Spo0A-P on the DNA template, perhaps preventing RNA polymerase from binding.

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The following have contributed to this page: Professor David A Dubnau and Andrew Tanner