Multiple Taf subunits of TFIID interact with Ino2 activation domains and contribute to expression of genes required for yeast phospholipid biosynthesis

What is it about?

Ino2 is an activator indispensable for regulated transcription of yeast genes of phospholipid biosynthesis such as INO1. Here we show that Ino2 directly interacts with five Taf subunits of general transcription factor TFIID. We identified functional minimal domains in Taf proteins (activator binding domains, ABDs) and demonstrated that Ino2 is needed to recruit Taf proteins to the INO1 promoter.

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