The three‐component system EsrISR regulates a cell envelope stress response in Corynebacterium glutamicum

What is it about?

In many Actinobacteria, a novel and unique type of two-component systems can be found whose hallmark is the presence of a PspC domain in their respective sensor kinases. Here, we elucidated the physiological function of the corresponding two-component system EsrSR of Corynebacterium glutamicum. We show that, together with its negative regulator EsrI, the resulting three-component system EsrISR regulates a broad and diverse cellular response to conditions that threaten the integrity of the cell envelope.

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