Effects of arginine on Streptococcus gordonii
What is it about?
This paper shows how an important oral bacterium senses and responds to arginine. External arginine concentration is shown to be a key factor for growth and biofilm formation. In fact, high concentrations of arginine (such as those currently used in some oral hygiene products) disrupt biofilms.
Why is it important?
There has been a lot of work recently around the concept of 'nutritional virulence', whereby nutrient scavenging systems of disease-causing bacteria have been shown to be important in pathogenicity. Here, we show that exogenous nutrients, and specifically L-arginine, are also an important factor for the colonization of oral bacteria. Key functions such as growth and biofilm formation are tightly regulated in response to L-arginine in an oral streptococcus.
The following have contributed to this page: Dr Nicholas S Jakubovics