What is it about?
The study seeks to assess the safety of artesunate and Amodiaquine combination in treatment of uncomplicated malaria in pregnancy. The results showed that heamatollogical and biochemical changes were mainly physiological and not primarily due to drug toxicity. However, in impaired hepatic state the drugs may exacerbate elevation of liver enzymes.
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Why is it important?
The study is important because of the increasing use of amodiaquine and artesunate combination in the management of uncomplicated malaria in pregnancy
Perspectives
The study seeks to assess the safety of artesunate and Amodiaquine combination in treatment of uncomplicated malaria in pregnancy. The results showed that heamatological and biochemical changes observed were mainly physiological and not primarily due to drug toxicity. However, in impaired hepatic state the drugs may exacerbate elevation of liver enzymes.
Dr Osede Ignis Iribhogbe
Ambrose Alli University EKpoma Edo State Nigeria
Read the Original
This page is a summary of: Assessment of the safety of non-fixed-dose combination of artesunate and amodiaquine for uncomplicated falciparum malaria in pregnancy: a nonrandomized open-label study, Journal of Pharmaceutical Health Services Research, January 2017, Wiley,
DOI: 10.1111/jphs.12166.
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