What is it about?
Chronic stress is a major contributor to the development of depression. This study aimed to evaluate the antidepressant-like effects of aqueous extracts of miswak (Salvadora persica) and date palm (Phoenix dactylifera) and their combination on depression-like behaviors using a chronic unpredictable mild stress (CUMS) rat model of depression and to investigate the underlying possible mechanisms via biochemical and molecular tests.
Photo by Clem Onojeghuo on Unsplash
Why is it important?
The findings of the current study provide extensive evidence for the application of aqueous extracts of miswak (Salvadora persica) or date palm (Phoenix dactylifera) and their combination in depression-like behaviors. The studied extracts effectively ameliorated depressive-like behaviors, bodyweight loss, and oxidative stress induced by CUMS in the rat model of depression and restored serotonin and cortisol secretion to normal levels. Furthermore, the studied extracts improved the levels of plasma pro-inflammatory cytokines and CREB and BDNF mRNA expression in the prefrontal cortex.
Read the Original
This page is a summary of: Antidepressant‐like effects of aqueous extracts of miswak (
) and date palm (
) on depression‐like behaviors using
..., Journal of Food Biochemistry, March 2022, Wiley, DOI: 10.1111/jfbc.14164.
You can read the full text:
The following have contributed to this page