What is it about?

Chronic stress is a major contributor to the development of depression. This study aimed to evaluate the antidepressant-like effects of aqueous extracts of miswak (Salvadora persica) and date palm (Phoenix dactylifera) and their combination on depression-like behaviors using a chronic unpredictable mild stress (CUMS) rat model of depression and to investigate the underlying possible mechanisms via biochemical and molecular tests.

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Why is it important?

The findings of the current study provide extensive evidence for the application of aqueous extracts of miswak (Salvadora persica) or date palm (Phoenix dactylifera) and their combination in depression-like behaviors. The studied extracts effectively ameliorated depressive-like behaviors, bodyweight loss, and oxidative stress induced by CUMS in the rat model of depression and restored serotonin and cortisol secretion to normal levels. Furthermore, the studied extracts improved the levels of plasma pro-inflammatory cytokines and CREB and BDNF mRNA expression in the prefrontal cortex.

Perspectives

I hope this article demonstrates the possibility of using aqueous extracts of miswak and date palm as an effective treatment for depressive-like behaviors caused by chronic stress.

Ehab Ibrahim
Ain Shams University

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This page is a summary of: Antidepressant‐like effects of aqueous extracts of miswak ( Salvadora persica ) and date palm ( Phoenix dactylifera ) on depression‐like behaviors using CUMS ..., Journal of Food Biochemistry, March 2022, Wiley, DOI: 10.1111/jfbc.14164.
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