What is it about?
The kidneys play a variety of important roles, one of which is the elimination of water-soluble drugs from the body. However, excessive renal excretion may increase the clearance of these compounds (i.e., antibiotics), which may decrease blood concentrations and reduce efficacy. This phenomenon is known to occur frequently in critically ill patients. However, we have shown that ARC occurs in patients with haematopoietic tumours as well, and then identified its risk factors and developed a scoring method for risk prediction.
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Why is it important?
The actual measurement of renal function is complicated and costly. Our method can easily assess ARC risk in haematologic cancer patients, suggesting that it is a useful screening tool in practice.
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This page is a summary of: A simple scoring method to predict augmented renal clearance in haematologic malignancies, Journal of Clinical Pharmacy and Therapeutics, June 2020, Wiley, DOI: 10.1111/jcpt.13193.
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