What is it about?

To evaluate the A to C nucleotide change located 202 bp upstream to the transcription start site, (-202 A/C polymorphism), in the insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) gene, and its association with renal carinogenesis and with clinicopathological characteristics.

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Why is it important?

Renal cell carcinoma (RCC) is the third leading cause of death among urological tumours. Insulin-like growth factors (IGFs) regulate cellular proliferation and differentiation. IGFB proteins (IGFBPs) regulate the action of IGFs. Polymorphism of the IGFBP-3 gene affects mean circulating IGFBP-3 concentrations. In this study, the AA genotype was significantly higher in patients with RCC than in controls. In addition, IGFBP-3 serum level was significantly higher in carriers of the A allele compared with non-carriers.


There are substantial studies linking IGF-I and IGFBP-3 to the evaluation of risk and prevention of cancer. However, the results from most of the published studies are not consistent. In a most recent pooled individual data analysis of 17 prospective studies, the role of IGF-I and IGFBP-3 in developing breast cancer was investigated. Circulating IGFI was positively associated with breast-cancer risk, but, the association was not substantially modified by IGFBP-3. Increased expression of IGFBP-3 has been reported in breast, prostate and pancreatic cancer cells

Dr Mohammad Reza Safarinejad
University of Medical Sceices

Read the Original

This page is a summary of: Insulin-like growth factor binding protein-3 (IGFBP-3) gene variants are associated with renal cell carcinoma, BJU International, February 2011, Wiley,
DOI: 10.1111/j.1464-410x.2010.10017.x.
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