What is it about?

To determine whether Thr(307)-Asn(680) and Ala(307)-Ser(680) polymorphisms of the follicle-stimulating hormone receptor (FSH-R) gene are associated with male infertility, semen quality, and reproductive hormones.

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Infertility affects 10–15% of couples. Men with impaired semen quality represent 40–50% of all infertile men. However, the cause of male infertility is still unknown in approximately 30% of cases. Genetic disorders are considered to account for 15–30% of male factor infertility. FSH plays a crucial role in both female and male reproduction [5]. In men, FSH regulates the function of testicular Sertoli cells, where spermatogenesis takes place.

Dr Mohammad Reza Safarinejad
University of Medical Sceices

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This page is a summary of: Evaluating the role of the FSH receptor gene Thr307-Ala and Asn680-Ser polymorphisms in male infertility and their association with semen quality and reproductive hormones, BJU International, November 2010, Wiley,
DOI: 10.1111/j.1464-410x.2010.09890.x.
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