What is it about?
The sequencing of the genome allowed the discovery of the genes responsible for cyanide metabolism, namely cyanide resistance and assimilation. Moreover, the complete sequence of the genome revealed the presence of genes and operons that could expand the biotechnological potential of this bacterial strain.
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Why is it important?
This publication reported the first genome sequence of a cyanide degrading bacterium, putting in context the genome sequence with the available biochemical and genetic information of this bacterium.
Perspectives
Nowadays the genome sequence of many bacteria is becoming available. This information is just the first steep for understanding the bacterial metabolism, which needs, at least, a supplementary manual annotation of the genes and adding further omics data, such as proteomics, metabolomics and so on. We hope that the integration of all this information into System Biology approaches will allow understanding, and therefore the possibility of manipulating, bacterial metabolism.
Dr. Rafael Blasco
Universidad de Extremadura
Read the Original
This page is a summary of: Draft whole genome sequence of the cyanide-degrading bacteriumPseudomonas pseudoalcaligenesCECT5344, Environmental Microbiology, September 2012, Wiley,
DOI: 10.1111/j.1462-2920.2012.02875.x.
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