What is it about?

This paper describes the development and validation of a safer, more practical testing method for detecting antibodies against Influenza D virus (IDV). The research addresses growing concerns about IDV's potential as a zoonotic threat by creating an improved assay that overcomes limitations of traditional testing methods.

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Why is it important?

Influenza D virus poses a significant zoonotic risk. Evidence of human exposure has been demonstrated through serological and molecular data, suggesting the virus may pose a public health risk and the zoonotic transmission of other adapted bovine influenza viruses underscores the need to monitor IDV. Traditional serological testing for IDV is challenging because traditional serological assays often require the handling of infectious viral isolates, which may not be available to all laboratories, and IDV does not produce a strong cytopathic effect in cell culture, making traditional microneutralisation assays more laborious. This new pseudotyped virus-based approach removes these barriers, making testing safer and more accessible globally.

Perspectives

It was really great to be able to adapt our influenza A/B pseudotype platform to incorporate influenza D and to carry out a qualification of this assay with expert groups from industry (VisMederi CRO, Italy).

Professor Nigel James Temperton
University of Kent

Read the Original

This page is a summary of: Development and Qualification of a Pseudotyped Virus‐Based Microneutralisation Assay for Influenza D Virus, Influenza and Other Respiratory Viruses, April 2026, Wiley,
DOI: 10.1111/irv.70245.
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