What is it about?
We investigatedwhether co-inheritance of alpha- and beta-thalassemia genes with sickle cell disease modified the severity of the disease.
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Why is it important?
This investigation is important because it demonstrated that association of two alpha-thalassemia genes with sickle cell disease led to considerable amelioration of the disease. This is useful information for genetic counselling - for example in prospective marriages between individuals who harbour these specific genes that are quite commonly inherited in the Middle-East region,
Perspectives
This is a special study because, interestingly, there are few available reports that investigated associations of specific alpha-thalassemia alleles prevalent in the Middle-East region with sickle cell disease. This is notwithstanding decades of research devoted to this disease.
Dr. DURJOY K. SHOME
ARABIAN GULF UNIVERSITY
Read the Original
This page is a summary of: Frequencies and phenotypic consequences of association of α- and β-thalassemia alleles with sickle-cell disease in Bahrain, International Journal of Laboratory Hematology, December 2016, Wiley,
DOI: 10.1111/ijlh.12577.
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