Pathological characterization and morphometric analysis of hepatic lesions in SHRSP5/Dmcr, an experimental non-alcoholic steatohepatitis model, induced by high-fat and high-cholesterol diet

What is it about?

In consequence of the current increase of obese population, non-alcoholic fatty liver disease (NAFLD) has attracted attention as the most-frequently observed hepatic disorder. NAFLD develops into more serious disease such as non-alcoholic steatohepatitis (NASH) and cirrhosis. Considering to the development of new drugs to NASH, animal model is very important. Recently, high-fat and high-cholesterol (HFC) diet-fed stroke-prone spontaneously hypertensive rat 5 (SHRSP5/Dmcr) has been reported as a novel rat model of developing hepatic lesions similar to human NASH. We investigated the detailed pathological conditions induced by HFC diet in SHRSP5/Dmcr using molecular biological methods and morphometric analysis. The clear feeding time-dependent progression of NASH-like hepatic lesion in HFC diet fed-SHRSP5/Dmcr reinforced the conclusion that this rat strain might be a useful model of NASH or inflammatory fibrotic disease conditions.

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Why is it important?

In this report, we investigated the detailed pathological conditions induced by HFC diet in SHRSP5/Dmcr using molecular biological methods and qunatitative analysis including morphometric image processing analysiswhich has not reported yet.

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