What is it about?
The current definition of HER2-low Breast cancer remains incomplete with low rates of interobserver concordance. This study aims to refine the HER2-low definition with emphasis on distinguishing HER2 score 0 from score 1+ to identify patients who are eligible for ADC.
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Why is it important?
After antibody-drug conjugate (Trastuzuman-deruxtecan) being approved for the treatment of HER2 low breast cancer patients, distinguishing patients that are HER2 IHC 1+ from IHC 0 became inevitable. This is the first study that refines the definition of HER2 1+ using HER2 RNA level and artificial neural network model with high interobserver concordance achieved.
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This page is a summary of: Refining the definition of
‐low class in invasive breast cancer, Histopathology, September 2022, Wiley,
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