Nuclease activity gives an edge to host-defense peptide piscidin 3 over piscidin 1, rendering it more effective against persisters and biofilms

M. Daben J. Libardo, Ali A. Bahar, Buyong Ma, Riqiang Fu, Laura E. McCormick, Jun Zhao, Scott A. McCallum, Ruth Nussinov, Dacheng Ren, Alfredo M. Angeles-Boza, Myriam L. Cotten
  • FEBS Journal, September 2017, Wiley
  • DOI: 10.1111/febs.14263

Fishing for new antibiotics

What is it about?

Understanding how peptides from fish eradicate bacteria.

Why is it important?

New antibiotics are desperately needed due to the rise of antibiotic-resistant pathogens. By understanding how antimicrobial agents work we can design effective antimicrobial treatments in the future.


Professor Alfredo M Angeles-Boza (Author)
University of Connecticut

Writing this article was a great pleasure as it is our second product of a collaboration with Prof. Myriam Cotten (College of William and Mary), an expert on piscidins and biophysics. It is also a collaboration with Prof. Ruth Nussinov who focuses on understanding molecular interactions using computational approaches. By combining our efforts we were able to get a better picture on how these magnificent products of nature provide an effective defense against pathogens.

The following have contributed to this page: Professor Alfredo M Angeles-Boza