What is it about?

Vesicouterine is an uncommon abnormal passage between the uterus and bladder, and patients may present with cyclical hematuria, menouria, amenorrhea, and/or urinary incontinence. This condition is normally confirmed through filling the bladder with dye or through cystoscopy. Our publication presents a case which was diagnosed solely through immunohistochemical analysis. Although preliminary hematoxylin-eosin stains of urine exfoliated cells seemed to suggest bladder malignancy, this was subsequently excluded through expression of normal endometrial gland and stroma cells.

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Why is it important?

Our publication is the first to report diagnosis of vesicouterine fistula through immunohistochemical analysis. Normally more invasive tests are used to diagnosis this issue, including blue methylene dye test and cystoscopy.


Writing this article allowed us to present diagnosis of a vesicouterine fistula, which is an interesting uncommon pathological phenomena normally diagnosed through invasive test methods. We hope that the diagnostic test methods that we presented allows for our readers to perform non-invasive diagnosis of the same problem when encountered clinically.

Yefang Huang
Hospital of Chengdu University of Traditional Chinese Medicine

Read the Original

This page is a summary of: Enigma portal case: Cytological diagnosis of vesicouterine fistula, Cytopathology, November 2021, Wiley,
DOI: 10.1111/cyt.13069.
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