What is it about?
Mannitol is a potentially very effective colonoscopy preparation that is very well accepted by patients. For the first time, a pharmacokinetic study was carried out on different dosages of mannitol also for to evaluate the optimal dose. The study showed that the bioavailability of the product is around 20%. The amount of drug absorbed increases with the dose; with 100 g the total amount of drug absorbed is still sufficiently reduced to guarantee a low incidence of systemic side effects. Elimination of the drug is rapid and is completed in less than 24 hours; clinical controls are therefore not necessary after the day of the colonoscopy.
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Why is it important?
Mannitol-based preparations for colonoscopy are widely used in different parts of the world but as off-label products and without a well establish the pharmacokinetic profile of the drug after oral intake. The current study for the first time confirms that the maximum blood concentration was dose-dependent, while bioavailability was similar at the three doses. All doses lead to peak mannitol concentration in the blood after 2.5 hours; the terminal half-life is short (2.5 hours), leading to complete drug elimination within 24 hours. Therefore, the occurrence of systemic side effects should be unlikely and, if occurring, self-resolving in a short time.
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This page is a summary of: Pharmacokinetics of oral mannitol for bowel preparation for colonoscopy, Clinical and Translational Science, August 2022, Wiley, DOI: 10.1111/cts.13373.
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