What is it about?

The review explains current reserach on functional aspects of PARP-1 in cell growth and survival which will help to expedite PARP research as a therapeutic potential.

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Why is it important?

The review focuses on the role of PARP-1 other equally important overlooked functions during growth, metabolic regulation, spermatogenesis, embryogenesis, epigenetics and differentiation. It will help to work on PARP-1 as a potential target for developmental diseases.


PARP-1 has for long been known to be an important regulator of DNA damage and repair. However, it has been found to be involved in a myriad of cellular events like growth, metabolic regulation, spermatogenesis, embryogenesis, epigenetics and differentiation via the conservation of genomic integrity, chromatin dynamics and transcriptional regulation. This compact but yet elaborate review will help researchers to widen their knowledge about the varied PARP-1 activities.

Rasheedunnisa Begum

Read the Original

This page is a summary of: The PARP family: insights into functional aspects of poly (ADP-ribose) polymerase-1 in cell growth and survival, Cell Proliferation, June 2016, Wiley,
DOI: 10.1111/cpr.12268.
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