Increment of height growth in patients with growth hormone insensitivity syndrome by cyproheptadine

What is it about?

Fifteen patients with growth hormone insensitivity syndrome were treated with Cyproheptadine hydrochloride orally 3 times a day. Treatment increased their height growth compared to the period of no treatment and also compared to 5 controls without treatment. There was no adverse event after 8 years of treatment.

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Why is it important?

This experience is very important because the current therapy of the patients with growth hormone insensitivity syndrome by IGF-I is very expensive and not available for every patient in different countries. It has some side effects that the most important is hypoglycemia and it is used by injection.

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