What is it about?
We demonstrated that ectopic expression in pancreatic cancer MIA PaCa-2 or PANC-1 cells of MUC6, either alone or combined with α4GnT, attenuates anchorage-dependent cell proliferation, cellular motility and cellular invasiveness in vitro.
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Why is it important?
We observed attenuation of malignant phenotypes following ectopic expression of MUC6 in pancreatic cancer cell lines, effects enhanced by co-expression of α4GnT in vitro. Moreover, in patient samples, higher A4GNT and MUC6 transcript levels were correlated with favorable prognosis in pancreatic ductal adenocarcinoma.
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This page is a summary of: Glycosylation of MUC6 by α1,4‐linked
‐acetylglucosamine enhances suppression of pancreatic cancer malignancy, Cancer Science, November 2021, Wiley, DOI: 10.1111/cas.15209.
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