Celastrol induces proteasomal degradation of FANCD2 to sensitize lung cancer cells to DNA crosslinking agents

Gui-Zhen Wang, Yong-Qiang Liu, Xin Cheng, Guang-Biao Zhou
  • Cancer Science, May 2015, Wiley
  • DOI: 10.1111/cas.12679

FANCD2 inhibitor

What is it about?

Celastrol is a FANCD2 inhibitor that could interfere with the monoubiquitination and protein stability of FANCD2

Why is it important?

Our results provide a novel opportunity to develop FA pathway inhibitor and combinational therapy for malignant neoplasms.

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The following have contributed to this page: Professor Guang-Biao Zhou